Saw palmetto extract: A dermatologist's perspective
نویسندگان
چکیده
منابع مشابه
Potency of a novel saw palmetto ethanol extract, SPET-085, for inhibition of 5alpha-reductase II.
INTRODUCTION The nicotinamide adenine dinucleotide phosphate (NADPH)-dependent membrane protein 5alpha-reductase irreversibly catalyses the conversion of testosterone to the most potent androgen, 5alpha-dihydrotestosterone (DHT). In humans, two 5alpha-reductase isoenyzmes are expressed: type I and type II. Type II is found primarily in prostate tissue. Saw palmetto extract (SPE) has been widely...
متن کاملSaw palmetto and benign prostatic hyperplasia.
Benign prostatic hyperplasia (BPH) is a common health issue that affects 8% of all men at the age of 40, 60% of men in their 70s, and 90% of those greater than 80 years of age. One-fourth of these men will develop moderate to severe lower urinary tract symptoms that greatly affect their quality of life. Recent evidence suggests that the use of saw palmetto leads to improvements in urinary funct...
متن کاملSaw palmetto berry extract inhibits cell growth and Cox-2 expression in prostatic cancer cells.
The cytotoxicity of a commonly used material to alleviate the symptoms of benign prostatic hyperplasia (BPH), Saw Palmetto Berry Extract (SPBE), was examined as neat oil using a set of prostatic cell lines; 267B-1, BRFF-41T and LNCaP. Proliferation of these prostatic derived cell lines is inhibited to different degrees when dosed for 3 days with SPBE. The amount of SPBE required to inhibit 50% ...
متن کاملIsolation and pharmacological characterization of fatty acids from saw palmetto extract.
Saw palmetto extract (SPE) has been widely used for the treatment of lower urinary-tract symptoms secondary to benign prostatic hyperplasia. The mechanisms of pharmacological effects of SPE include the inhibition of 5alpha-reductase, anti-androgenic effects, anti-proliferative effects, and anti-inflammatory effects. Previously, we showed that SPE bound actively to alpha(1)-adrenergic, muscarini...
متن کاملPharmacological effects of saw palmetto extract in the lower urinary tract
Saw palmetto extract (SPE), an extract from the ripe berries of the American dwarf palm, has been widely used as a therapeutic remedy for urinary dysfunction due to benign prostatic hyperplasia (BPH) in Europe. Numerous mechanisms of action have been proposed for SPE, including the inhibition of 5alphareductase. Today, alpha(1)-adrenoceptor antagonists and muscarinic cholinoceptor antagonists a...
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ژورنال
عنوان ژورنال: Indian Journal of Drugs in Dermatology
سال: 2017
ISSN: 2455-3972
DOI: 10.4103/ijdd.ijdd_45_16